Centers
Pediatric Center of Excellence in Nephrology (PCEN)
The organizing goal of Washington University’s Pediatric Center of Excellence in Nephrology is to provide a spatially resolved multiomic molecular blueprint of gene regulation and expression across the pediatric lifespan in healthy and disease conditions and related educational opportunities and bioresources to the community.
Through these resources, innovations in educational activities, cross-species molecular maps and analyses in humans and preclinical models we aim to transform the field of pediatric research, attract new expertise and strategies to keep kidneys healthy in children.
Labs
Halabi Lab
Carmen Halabi, MD, PhD
Our lab’s overall focus is to understand how vascular elastic fibers, large arteries’ main extracellular matrix, develop and how abnormalities in their development lead to diseases such as aneurysms and hypertension.
Hruska Lab
Keith A. Hruska, MD
Our laboratory’s focus is the pathogenesis and pathophysiologic mechanisms of the chronic kidney disease-bone and mineral disorder (CKD-MBD). Kidney diseases produce a complex set of body-wide complications. Some of these contribute to the mortality of kidney diseases, which is not due to the disease itself but largely due to associated cardiovascular disease. Cardiovascular disease risk in CKD is contributed to by non-traditional risk factors which are components of the CKD-MBD syndrome.